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SM 324405

CAS No. 677773-91-0

SM 324405( —— )

Catalog No. M21108 CAS No. 677773-91-0

SM 324405 is an ?agonist of TLR7.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SM 324405
  • Note
    Research use only, not for human use.
  • Brief Description
    SM 324405 is an ?agonist of TLR7.
  • Description
    SM 324405 is an ?agonist of TLR7.
  • In Vitro
    SM-324405 is a novel candidate for immunotherapy of allergic diseases.
  • In Vivo
    SM-324405 (9e, intratracheal administration) effectively inhibits allergen-induced airway inflammation without inducing cytokines systemically.SM-324405 is metabolized to the corresponding acid in human plasma with t1/2 of 2.6 min.
  • Synonyms
    ——
  • Pathway
    Immunology/Inflammation
  • Target
    TLR
  • Recptor
    TLR7
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    677773-91-0
  • Formula Weight
    385.42
  • Molecular Formula
    C19H23N5O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (129.73 mM)
  • SMILES
    CCCCOc1nc(N)c2[nH]c(=O)n(Cc3cccc(CC(=O)OC)c3)c2n1
  • Chemical Name
    Methyl 3-[(6-amino-2-butoxy-78-dihydro-8-oxo-9H-purin-9-yl)methyl]benzeneacetate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kurimoto A Hashimoto K Nakamura T.Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept[J].J Med Chem. 2010 Apr 8 ;53(7):2964-72.
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